Irinotecan is a semi-synthetic derivative of camptothecin, an alkaloid extract from camptotheca acuminata. 5-FU is an analogue of uracil with a fluorine atom at the C-5 position in place of hydrogen . Based on animal data with irinotecan HCl and its mechanism of action, irinotecan liposome can cause fetal harm when administered during pregnancy. Oxaliplatin and cisplatin are structurally distinct, but form the same types of adducts at the same sites on DNA [9–13]. Based on the mechanism of action as well as animal data using irinotecan (conventional), irinotecan (liposomal) may cause fetal harm if administered during pregnancy. The drug and its active metabolite are believed to exert their … The plasma metabolic signature of irinotecan exposure provides early insights into irinotecan mechanism of action in patients. Patient Education. Camptothecin and its analogue belong to the class of topoisomerase I inhibitors. What is this drug used for? There are no available data in pregnant women; however, irinotecan crosses the placenta of rats after intravenous administration. Accumulations of circulating acylcarnitines and specific amino acid metabolites may reflect, at least in part, irinotecan‐induced mitochondrial dysfunction and oxidative stress in the liver. Pharmacokinetics in Special Populations: Geriatric: In studies where irinotecan hydrochloride was administered weekly, the terminal half-life of irinotecan hydrochloride was 6.0 hours in patients who were 65 years or older, and 5.5 hours in patients younger than 65 years. Irinotecan and its active metabolite, SN-38, bind to the topoisomerase DNA complex, preventing religation of the single-strand breaks in the DNA molecule.
In physiological conditions, oxaliplatin forms DNA adducts that are not at dynamic equilibrium . • It is used to treat pancreatic cancer.
Intracellular targets and mechanisms of action. The plasma metabolic signature of irinotecan exposure provides early insights into irinotecan mechanism of action in patients. The clarification of the mechanisms of action and resistance of topotecan and CPT-11 should enable us to understand their pharmacological behavior even better and might lead to the development of more potent camptothecinderivatives in the future. Frequently reported side effects of this drug • Mouth irritation • Mouth sores
Mechanism of action of 5-FU.