trouble breathing. ([2014, Nov -]): 3. These work by stopping the growth of the protozoa that cause diarrhea. Other, less serious side effects may be more likely to occur. Description: Nitazoxanide is an antiprotozoal agent which impairs the anaerobic metabolism of susceptible organisms via the interference of the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction.In vitro, it inhibits the growth of sporozoites and oocysts of Cryptosporidium parvum and the trophozoites of Giardia lamblia. Call your doctor for medical advice about side effects. Nitazoxanide does not appear to cause any significant adverse effects when taken by healthy adults. Tizoxanide (the active metabolite of nitazoxanide) is highly bound to plasma protein (>99.9%). Along with its needed effects, a medicine may cause some unwanted effects. 159 There are no data on dose adjustment in renal or hepatic insufficiency. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Some side effects may not be reported. vitamins, herbal supplements, etc. However, safety and efficacy of nitazoxanide oral suspension has not been established in children younger than 1 year of age. Possible serious side effects of nitazoxanide include: Lung disease; Pharyngitis; Fast heart beat; Fainting; Low blood pressure; Painful urination; Painful or no menstruation; Kidney pain; Anemia; Increased white blood cells; Spontaneous bone fracture This medication comes as a suspension (liquid) and tablet to take by mouth and is usually taken every 12 hours with food. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Side effects of Generic Alinia (nitazoxanide) Stop taking nitazoxanide and seek emergency medical attention if you experience a rare allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives). The most common adverse reactions in ≥2% of patients were abdominal pain, headache, chromaturia and nausea. You may need to have tests done to check that the infection is cleared. Other side effects not listed may also occur in some patients. Nitazoxanide belongs to a group of drugs called antiprotozoal agents. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Adverse events occurring in <1% of more than 2000 HIV-uninfected patients participating in clinical trials included anorexia, flatulence, increased appetite, enlarged salivary glands, fever, infection, malaise, elevated creatinine levels, elevated levels of alanine a… This site complies with the HONcode standard for trustworthy health information: verify here. vomiting. Placebo-controlled studies. Gastroesophageal Reflux Disease. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Do not take this medicine if you have a known allergy to it. Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. Alinia (nitazoxanide)." Nitazoxanide Side Effects. Change in color of urine. Nitazoxanide is a light yellow crystalline powder. Along with its needed effects, nitazoxanide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. The side effects of nitazoxanide do not significantly differ from a placebo treatment for giardiasis; these symptoms include stomach pain, headache, upset stomach, vomiting, discolored urine, excessive urinating, skin rash, itching, fever, flu syndrome, and others. Lancet Infect Dis. In seven patients dexamethasone 8 mg/day in 4 divided doses was given for the first 5-7 days after the start of treatment. A Skin Rash. Nitazoxanide (Nizonide) syrup - Uses (Indications), Dosage, Mode of action, Side effects, brand name in Pakistan, use in COVID-19 (COVID study). redness of the skin. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. 2. Call your doctor for medical advice about side effects. Call your doctor for medical advice about side effects. RARE side effects. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions, warnings etc. Nitazoxanide - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Medindia Incidence not known. hives or welts, itching, or skin rash. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you experience any of these symptoms, call your doctor immediately: skin rash; itching; Nitazoxanide may cause other side effects. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Nitazoxanide is a light yellow crystalline powder. Although not all of these side effects may occur, if they do occur they may need medical attention. DESCRIPTION. Epub 2020 Feb 27. Clin Infect Dis 40 (2005): 1173-80. pregnancy, upcoming surgery, etc. Side effects What side effects can occur from Nitazoxanide? Adverse events have been mild and transient and principally related to the gastrointestinal tract, such as abdominal pain, diarrhea, and nausea. Portions of this document last updated: Feb. 01, 2020. Antiepileptic treatment was continued. [Ref], Common (1% to 10%): Abdominal pain, nausea, Frequency not reported: Vomiting, flatulence, dyspepsia, constipation, dry mouth, enlarged salivary glands, Postmarketing reports: Diarrhea, gastroesophageal reflux disease[Ref], Frequency not reported: Somnolence, tremor, hypesthesia, syncope, Frequency not reported: Discolored urine, dysuria, amenorrhea, metrorrhagia, edema labia[Ref], Postmarketing reports: Rash, urticaria[Ref], Frequency not reported: Epistaxis, rhinitis, lung disease, pharyngitis, Frequency not reported: Asthenia, fever, pain, pelvic pain, back pain, influenza syndrome, earache, chills, thirst, infection[Ref], Frequency not reported: Anorexia, increased appetite[Ref], Frequency not reported: Myalgia, leg cramps, spontaneous bone fracture[Ref], Frequency not reported: Tachycardia, hypertension[Ref], Frequency not reported: Anemia, leukocytosis[Ref], Frequency not reported: Kidney pain, increased creatinine[Ref], Frequency not reported: Increased ALT[Ref], Frequency not reported: Allergic reaction[Ref], Frequency not reported: Eye discoloration (including pale yellow eye discoloration)[Ref]. All drugs may cause side effects. Chen L, Xiong J, Bao L, Shi Y. Convalescent plasma as a potential therapy for COVID-19. Side effects were generally mild. 2012 May;13(1):23-7. doi: 10.1016/j.intimp.2012.03.002. Mayo Clinic does not endorse companies or products. dazole and nitazoxanide ex ert essentially differential effects on G. duoden alis tr ophozoites in vitro, with respect to morpho- logical and ultr astructural alter ations, also suggesting that the Visit your doctor or health care professional for a follow-up visit as directed. What should I watch for? Nitazoxanide may cause side effects. These side effects may go away during treatment as your body adjusts to the medicine. Available for Android and iOS devices. If you notice any other effects, check with your healthcare professional. This is not a complete list of side effects and others may occur. You may report side effects … Nitazoxanide is generally well tolerated, and no significant adverse events have been noted in human trials. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Practice good hygiene to prevent infection of others. Dizziness. Nitazoxanide side effects Central Nervous System- Headache. This content does not have an Arabic version. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. 25. Stomach pain. 2020 Apr;20(4):398-400. doi: 10.1016/S1473-3099(20)30141-9. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. If you notice any other effects, check with your healthcare professional. "Product Information. Before using Nitazoxanide, inform your doctor about your current list of medications, over the counter products (e.g. These side effects may go away during treatment as your body adjusts to the medicine. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online. Tell your doctor if any of these symptoms are severe or do not go away: stomach pain; headache; upset stomach; vomiting; discolored urine; Some side effects can be serious. Gastrointestinal- Abdominal pain, diarrhea, nausea, vomiting. ), allergies, pre-existing diseases, and current health conditions (e.g. This is not a complete list of side effects and others may occur. Common side effects may include: nausea, stomach pain; headache; or; discolored urine. Int J Clin Pharmacol Ther 40 (2002): 221-7, 4. The molecular formula is C 12 H 9 N 3 O 5 S and the molecular weight is 307.3. Upset stomach. Trouble Breathing. Stockis A, De Bruyn S, Gengler C, Rosillon D "Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d." Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. A very serious allergic reaction to this drug is rare. Common side effects of nitazoxanide include: Diarrhea; Nausea; Abdominal pain; Headaches; Other side effects of nitazoxanide include: Asthenia (weakness) Fever; Pain; Allergic reaction; Chills; Flu syndrome; Dizziness; Drowsiness; Insomnia; Tremor; Vomiting; Dyspepsia (upset stomach) Anorexia; Flatulence; Constipation; Dry mouth, thirst; Discolored urine; Rash; Pruritus Nitazoxanide storage conditions Oral: Suspension: Store it at 15-30°C (59-86°F). Pharmacology Pharmacodynamics. Nitazoxanide is well tolerated when administered in the recommended dose, with reported side effects being no different than placebo. 500 mg Nitazoxanide taken orally every 12 hours with food for 3 days. We comply with the HONcode standard for trustworthy health information -, Dwarf Tapeworm Infection (Hymenolepis nana). Melbourne: Therapeutic Guidelines Limited "eTG complete [Online] Available from: URL: http://online.tg.org.au/complete/desktop/tgc.htm." It is given by the oral route with good bioavailability and is well tolerated, with primarily mild gastrointestinal side effects. 1. ALINIA Tablets and ALINIA for Oral Suspension contain the active ingredient, nitazoxanide, a synthetic antiprotozoal for oral administration. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. If you have any unusual effects, contact your doctor or pharmacist promptly. Epub 2012 Mar 17. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Chemically, nitazoxanide is 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Last updated on Apr 8, 2020. All rights reserved. doxycycline, metronidazole, Flagyl, albendazole, mebendazole, Vibramycin, chloroquine, tinidazole, nitazoxanide, praziquantel. Side Effects of Drugs, Annual 23 J.K. Aronson, ed. Tell your doctor if your symptoms do not improve or if they get worse. Medically reviewed by Drugs.com. Fox LM, Saravolatz LD "Nitazoxanide: a new thiazolide antiparasitic agent." There is no information about the presence of nitazoxanide in human milk, the effects on the breast-fed infant, or the effects on milk production. Buy Nizonide 500 Tablet Online. Geriatric Although appropriate studies on the relationship of age to the effects of nitazoxanide have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of nitazoxanide in the elderly. Oral doses of 4 grams in healthy adults do not appear to cause any significant adverse effects. discolored urine. Common side effects may include: nausea, stomach pain; headache; or. You may report side effects to the FDA at 1-800-FDA-1088. Full Drug Information. All rights reserved. However, get medical help right away if you notice any symptoms of a serious allergic reaction, such as: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, … Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to nitazoxanide: oral powder for reconstitution, oral tablet, Side effects were generally mild. Nitazoxanide Use as Part of an Empiric Multi-Drug Regimen in Treating Children with Suspected Helicobacter pylori Infection May 2015 Case Reports in Gastroenterology 9(1):36-42 Likewise, there are no data on safety in pregnancy, although reproductive toxicity studies in laboratory animals undertaken by the manufacturer have not revealed any adverse findings. Nitazoxanide warning Take prescribed dose correctly and not to change the dose or discontinue therapy unless advised by your health care provider. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Dizziness. Nitazoxanide suppresses IL-6 production in LPS-stimulated mouse macrophages and TG-injected mice.