The Dhh-cre transgene harbors a nuclear-localized Cre recombinase gene under control of the mouse desert hedgehog ( Dhh ) promoter/regulatory regions. The gene, desert hedgehog (DHH) plays a role in testis determination [1, 3, 4] and its protein product, produced by Sertoli cells, promotes Leydig cell development by activating Hedgehog signalling [3, 5]. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling … The hedgehog signaling pathway is a system of genes and gene products, mostly proteins, that convert one kind of signal into another, called transduction. The mouse Desert hedgehog gene is expressed in the developing gonad, endothelium, and Schwann cells (12). Desert hedgehog (DHH) is a member of the hedgehog gene family which act as secreted intercellular signal transducers [].Hedgehog was first identified as a segment polarity gene in Drosophila and has since been identified as a key regulator of pattern formation in embryonic and adult development in many vertebrate and invertebrate species. Thus, through this Sertoli-Leydig cell interaction, DHH also regulates androgen synthesis and is involved in sex differentiation. categorized into three subgroups: the Desert Hedgehog (Dhh), Indian Hedgehog (Ihh), and Sonic Hedgehog (Shh) groups (Echelard et al. By similarity The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. Desert Hedgehog (Dhh) belongs to the highly conserved Hedgehog family of proteins which are involved in multiple developmental processes. The hedgehog signaling pathway works both between cells and within individual cells. Hedgehog proteins are important for early development in many parts of the body. We have identified six patients with 46,XY DSD with seven novel DHH gene variants. Thus, this molecule holds great therapeutic potential for biotechnological and biomedical approaches aiming to enhance tissue regeneration or to replace damaged tissues. The Hedgehog Signaling Pathway in Vertebrates The hedgehog signaling pathway is a mechanism that regulates cell growth and differentiation during embryonic development, called embryogenesis, in animals. This protein is predicted to be made as a precursor that is autocatalytically cleaved\; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. The hedgehog gene family encodes signaling molecules that play an important role in … The desert hedgehog protein N-product binds calcium and zinc ions; this stabilizes the protein fold and is essential for protein-protein interactions mediated by this domain. Mammalian hedgehog genes share striking homology to the Drosophila segment polarity gene hedgehog, a key regulator of pattern formation in the embryonic and adult fly. Entrez Gene Summary for DHH Gene This gene encodes a member of the hedgehog family. 2 Publications Manual assertion based on experiment in i Background: Desert Hedgehog/Dhh. The DHH gene provides instructions for making a member of the hedgehog protein family. Desert hedgehog, also Desert hedgehog homolog or Dhh, is a protein encoded by the DHH gene, and is a member of the hedgehog signaling pathway.The human homolog (DHH) is on chromosome band 12q13.1.
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